Endocrine Abstracts

Th17 cells represent newly discovered CD4+T cells producing predominantly IL17A cytokines, which are involved in inflammations and autoimmune diseases. Elevated IL17 levels were demonstrated in thyroid autoimmunity and the activity of Graves’ ophthalmopathy. The relationship among IL17A, anti-thyroid antibodies, smoking, and clinical activity score of ophthalmopathy was investigated in hyperthyroid Graves’ disease. One hundred and thirty-eight patients, 62 with Grave...

Postmenopausal osteoporosis is characterized by lower bone mass, loss of structural integrity, and sometimes becomes life-threatening. The development of postmeno-pausal osteoporosis is multifactorial. Estrogen plays a preventing role in the bone resorption inhibiting the secretion of proinflammatory IL1 and TNFα cytokines. IL17 proinflammatory citokine is a new candidate in the pathogenesis of osteoporosis. IL17 levels are increased in estrogen deficiency.<p class="a...

IL17 proinflammatory cytokine through T cell activation has prominent bone-wasting effect. Our previous results highlighted the role of IL17 in postmenopausal osteoporosis. To demonstrate the HLA allele association with the increased IL17 levels in postmenopausal osteoporosis was the object of the study.HLA class I and II alleles were measured in 64 postmenopausal women (in four subgroups: with low IL17 (1, 3) and high (>3.04 pmol/l) IL17 levels (2, ...